Road traffic crashes and prescribed methadone and buprenorphine

Last year, a study questioned whether buprenorphine patients should be allowed to drive because 60% tested positive for other drugs. Now, another study reaches similar findings: Background Opioids have been shown to impair psychomotor and cognitive functioning in healthy volunteers with no history of opioid abuse. Few or no significant effects have been found in opioid-dependant … Continue reading Road traffic crashes and prescribed methadone and buprenorphine

n=8

Published in a prestigious journal with an 'n' of 8. Unbelievable. Participants  Eight cocaine-using adults. Measurements  Subjects completed nine experimental sessions in which they were pre-treated with 0, 100 or 200 mg oral immediate release bupropion. Ninety minutes later they sampled an intranasal cocaine dose [4 (placebo), 15 or 45 mg] and made six choices between that dose and … Continue reading n=8

Human rights and coerced treatment

  A recent article looks at the ethics and effectiveness of coerced treatment: It has been argued that quasi-compulsory treatment (QCT) may be considered ethical (under some specific conditions) for drug dependent offenders who have committed criminal offences for whom the usual penal sanction would be more restrictive of liberty than the forms of treatment … Continue reading Human rights and coerced treatment

Emotional pain without context

Siddhartha Mukherjee provides a brief history of the serotonin hypothesis of depression, its demise and why dismissing serotonin may be an "overcorrection." Part of this story is an emerging theory of depression: A remarkable and novel theory for depression emerges from these studies. Perhaps some forms of depression occur when a stimulus — genetics, environment … Continue reading Emotional pain without context