From the recently updated NIAAA fact sheet on alcohol and health:
An estimated 95,000 people (approximately 68,000 men and 27,000 women) die from alcohol-related causes annually, making alcohol the third-leading preventable cause of death in the United States. The first is tobacco, and the second is poor diet and physical inactivity.
Of course, there are lots of other social costs associated also with alcohol and tobacco.
This should prompt reflection and planning as move toward decriminalizing and celebrating other drugs.