Recent studies found baclofen to be no more effective than placebo and topiramate more effective than naltrexone.
UPDATE: Yikes. This is embarrassing. Brian pointed out in the comments below that I wrongly indicated that baclofen and topiramate are the same drug. They aren’t. The post has been corrected.
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Published by Jason Schwartz
I have been an addiction professional and social worker since 1994. I started blogging in 2005 as the Clinical Director at Dawn Farm. I no longer work at Dawn Farm and am now the Director of Behavioral Medicine at a community hospital, and a lecturer at Eastern Michigan University’s School of Social Work.
Views expressed here are my own.
Keep in mind that the field, the contexts in which the field operates, and my views have changed over time.
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Topiramate and Baclofen are not the same drug, nor do they necessarily have the same site of action. Baclofen pretty clearly hits the GABAb receptors, whereas topiramate potentially has multiple actions, inter and intracellular. Your first link is a comparison of baclofen with placebo. Your second compares topiramate and naltrexone – interesting link at that – thanks for bringing it to our attention.
Well, that’s embarrassing. Thanks for correcting me.