More Research

Dopamine receptor deficiency leads to significant brain changes in response to drinking

“This study shows that the effects of chronic alcohol consumption on brain chemistry are critically influenced by an individual’s pre-existing genetic makeup,” said lead author Panayotis (Peter) Thanos, a neuroscientist with Brookhaven Lab and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) Laboratory of Neuroimaging. “Our findings may help explain how someone’s genetic profile can interact with the environment — in this case, chronic alcohol drinking — to produce these changes only in some individuals, but not in others with a less vulnerable genetic profile. The work supports the idea that genetic screening could provide individuals with valuable information relevant to understanding risks when deciding whether or not to consume alcohol.”

2 thoughts on “More Research

  1. Jason,
    If I read correctly the environmental factor was the 40 proof water. The mice who lacked D2 and drank the alcoholic beverage had down regulation of CB1, while the mice who lacked D2 and drank plain water had up regulation of CB1.

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