Salon recently posted a history of cocaine. Has PHARMA changed at all? For serious cocaine consumers, other products were also available in the late nineteenth century. Large drug companies such as Parke-Davis in Detroit also got into the cocaine game. They developed processes for the mass production of easily crystallizable and soluble salts like hydrochloride, which … Continue reading Some things never really change
A recent study on the use of topiramate for cocaine addiction has been getting a lot of attention. Most of the coverage draws only from the researchers press release. “Using an intent-to-treat analysis, the researchers found that topiramate was more efficacious than placebo at increasing the participants’ weekly proportion of cocaine nonuse days and in … Continue reading A drug to treat cocaine addiction?
Thank you, Stephanie Pappas from LiveScience! "The study performed cannot determine whether Oreos are as addictive as cocaine," said Edythe London, a researcher at the University of California, Los Angeles, who uses brain imaging to study the neural basis of drug cravings. "That question is best addressed in a comparison of how hard a rat will … Continue reading No, Oreos are not as addictive as cocaine
Yesterday I posted about a recent NY Times column arguing for a rational model of addictive drug use: “When they were given an alternative to crack, they made rational economic decisions.” … When methamphetamine replaced crack as the great drug scourge in the United States, Dr. Hart brought meth addicts into his laboratory for similar … Continue reading If it wasn’t rational, cont’d
Dirk Hansen reports the good news about "crack babies": In a paper authored by Hurt, Laura M Betancourt, and others, the investigators write: “It is now well established that gestational cocaine exposure has not produced the profound deficits anticipated in the 1980s and 1990s, with children described variably as joyless, microcephalic, or unmanageable.” The authors do … Continue reading What happened to the “crack babies”?
Another study supports the effects of twelve step participation over 24 months. (I know the abstract says "self help", but the pay-walled article makes it clear that they were looking at twelve step participation.) Abstract The goal was to identify factors that predicted sustained cocaine abstinence and transitions from cocaine use to abstinence over … Continue reading 24 month outcomes
Stimulant maintenance therapy did not work 🙁 This study did not find a significant main effect of modafinil on the rate or duration of cocaine use among cocaine-dependent patients. Now they decide to polish the turd: Although these results are disappointing, we did find that modafinil-treated patients had nonsignificantly higher odds of attaining abstinence across … Continue reading They’ve got hope for something. But, what?
Published in a prestigious journal with an 'n' of 8. Unbelievable. Participants Eight cocaine-using adults. Measurements Subjects completed nine experimental sessions in which they were pre-treated with 0, 100 or 200 mg oral immediate release bupropion. Ninety minutes later they sampled an intranasal cocaine dose [4 (placebo), 15 or 45 mg] and made six choices between that dose and … Continue reading n=8
A recent study gets into some of the nitty gritty of substance use disorders and interpersonal violence (IPV): Alcohol use disorders and cocaine use disorders were most strongly associated with IPV perpetration, while cannabis use disorders and opioid use disorders were most strongly associated with IPV victimization. A diagnosis of both an alcohol use disorder … Continue reading Drilling down into DV and drugs