Siddhartha Mukherjee provides a brief history of the serotonin hypothesis of depression, its demise and why dismissing serotonin may be an "overcorrection." Part of this story is an emerging theory of depression: A remarkable and novel theory for depression emerges from these studies. Perhaps some forms of depression occur when a stimulus — genetics, environment … Continue reading Emotional pain without context
Category: Research
Evidence-based policy wrong-headed
Keith Humphreys rejects the notion of evidence based policy: ...what we do with scientific evidence is always a political and moral judgment. We don’t provide health care to the sick because the evidence forces us to. We provide health care to the sick because such activity is in keeping with our values. Likewise, we might choose to … Continue reading Evidence-based policy wrong-headed
Only 2.6% of welfare applicants test positive
Not surprisingly, drug testing of welfare recipients does not confirm the assumptions of supporters: Of the 4,086 applicants who scheduled drug tests while the law was enforced, 108 people, or 2.6 percent, failed, most often testing positive for marijuana. About 40 people scheduled tests but canceled them, according to the Department of Children and Families, … Continue reading Only 2.6% of welfare applicants test positive
12-step involvement and continuous abstinence at 2 years
More support for twelve step facilitation and sober housing: Participants who were categorically involved in 12-step activities were significantly more likely to maintain continuous abstinence at 2 years compared with those who were less involved, predicting a greater likelihood of complete abstinence than summary scores of involvement. In addition, participants in the Oxford House condition … Continue reading 12-step involvement and continuous abstinence at 2 years
How Exercise Can Prime the Brain for Addiction
This makes sense, but is a weird thing to think about. Drug addiction may be more difficult to kick if it became habitual while exercise if part of your routine: It does indicate that shedding an addiction acquired when a person has been exercising could be extra challenging, he says. “But, really, what … Continue reading How Exercise Can Prime the Brain for Addiction
Memory ‘trick’ relieves drug cravings
We've previously posted about the use of medications like propranolol to interfere with memory reconsolidation and reduce the power of addicts' neurological triggers to get high. Chinese researchers are experimenting with non-pharmaceutical approaches to using memory reconsolidation to reduce craving: Addicts tend to associate a drug's effects with drug-taking equipment and a certain environment, which can make … Continue reading Memory ‘trick’ relieves drug cravings
Criminal charges before and after initiation of buprenorphine maintenance
I would have thought this was a softball in support of buprenorphine. But, no: Among subjects with prior criminal charges, initiation of office-based buprenorphine treatment did not appear to have a significant impact on subsequent criminal charges. The paper gets a little says that this lack of effect includes drug charges. I'm no fan of … Continue reading Criminal charges before and after initiation of buprenorphine maintenance
Twelve-Step attendance trajectories over 7 years among adolescents
More evidence for the benefits of 12 step facilitation for adolescents: Results of multivariate logistic GEE models indicated that adolescents with continued 12-Step attendance had better outcomes over time, whereas those in the early but not continued group had no different long-term outcomes compared to those in the low/no attendance group. A problem, of course, … Continue reading Twelve-Step attendance trajectories over 7 years among adolescents
Nicotine replacement ineffective
A recent study found nicotine replacement ineffective: In the prospective cohort study the researchers, including lead author Hillel Alpert, research scientist at HSPH, and co-author Lois Biener of the University of Massachusetts Boston’s Center for Survey Research, followed 787 adult smokers in Massachusetts who had recently quit smoking. The participants were surveyed over three time … Continue reading Nicotine replacement ineffective
Buprenorphine Maintenance and Health Care Professionals
Mayo Clinic Proceedings published a new article entitled, Buprenorphine Maintenance Therapy in Opioid-Addicted Health Care Professionals Returning to Clinical Practice: A Hidden Controversy. From the article: When considering all of the aforementioned issues with buprenorphine diversion, it does not seem reasonable to prescribe this medication to an HCP (Health Care Professional) with a history of opioid … Continue reading Buprenorphine Maintenance and Health Care Professionals
Recovery Review 